解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Colon cancer is the third leading cause of death from cancer worldwide with less than 10% survival rate at the late stage. Although mutations of certain genes have been implicated in familial colon cancer development, the etiology of the majority of colon cancer remains unknown. Herein, we identified TYRO3 as a potent...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.120
更新日期:2016-11-10 00:00:00
abstract::Acute myeloid leukemia (AML) is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype carries the t(6;9)(p22;q34) chromosome rearrangement, which leads to expression of the DEK-NUP214 chimeric gene, and has a particularly poor outcome. To provide a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.118
更新日期:2016-10-27 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected by stromal microenvironment. Based on previous observations that CLL cells exhibit mitochondrial dysfunction and altered lipid...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.103
更新日期:2016-10-27 00:00:00
abstract::A lot of attention has been dedicated to investigate the role of the tyrosine kinase receptor MET in tumors. The acquired notion that cancer cells from different histological origin strictly rely on the engagement of this specific oncogene for their growth and survival has certainly justified the development and the u...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.36
更新日期:2016-10-20 00:00:00
abstract::The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels were observed in recu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.75
更新日期:2016-10-13 00:00:00
abstract::Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.58
更新日期:2016-10-06 00:00:00
abstract::Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.40
更新日期:2016-09-22 00:00:00
abstract::In breast cancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that response to surgery may have a causative role. Radiotherapy (RT) after lumpectomy significantly reduces the risk of recurrence. We investigated the direct effects of surgery and of RT delivered intraoperati...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.23
更新日期:2016-09-15 00:00:00
abstract::Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA-damaging agents, defects on both t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.16
更新日期:2016-09-15 00:00:00
abstract::Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through cyclin-dependent kinase (CDK) inhibition has therefore emerged as an attractive option in the development of targ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.32
更新日期:2016-09-15 00:00:00
abstract::The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.3
更新日期:2016-09-01 00:00:00
abstract::Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma cell li...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.504
更新日期:2016-08-18 00:00:00
abstract::Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.503
更新日期:2016-08-18 00:00:00
abstract::The serine threonine checkpoint kinase 2 (CHK2) is a critical protein involved in the DNA damage-response pathway, which is activated by phosphorylation inducing cellular response such as DNA repair, cell-cycle regulation or apoptosis. Although CHK2 activation mechanisms have been amply described, very little is known...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.495
更新日期:2016-08-18 00:00:00
abstract::The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small. There is a need to discover new potential actionable genetic lesions, to which end, non-conventional cancer pathways, such as RN...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.469
更新日期:2016-08-18 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is as...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.481
更新日期:2016-08-04 00:00:00
abstract::Progesterone receptor (PR) is usually co-localized with estrogen receptor (ER) in normal mammary cells. It is not known whether ER/PR-negative human breast cancer arises from an ER/PR-negative cell or from an ER/PR-positive cell that later lost ER/PR. Using intraductal injection of a lentivirus to deliver both an onco...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.465
更新日期:2016-08-04 00:00:00
abstract::Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2015.454
更新日期:2016-07-21 00:00:00
abstract::Downregulation of E-cadherin by the transcriptional repressor Snail is associated with acquisition of metastatic potential. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, it is unclear whether Snail is involved in HCV core-induced dysregulation of E-cadherin. Herein, we inve...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.428
更新日期:2016-07-14 00:00:00
abstract::The crizotinib-resistant ALK(F1174L) mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel anaplastic lymphoma kinase (ALK) inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivative ceritinib (LDK3...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.434
更新日期:2016-07-14 00:00:00
abstract::The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss als...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.399
更新日期:2016-06-30 00:00:00
abstract::Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.394
更新日期:2016-06-23 00:00:00
abstract::In light of a detailed characterization of genetic aberrations in cancer, nucleic acid targeting represents an attractive therapeutic approach with significant translational potential. Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer deaths worldwide with stagnant 5-year survival rates. Advan...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2015.424
更新日期:2016-06-23 00:00:00
abstract::Activation of hypoxia-inducible factor (HIF) is due to loss of von Hippel-Lindau protein (pVHL) function in most clear cell renal cell carcinomas (ccRCCs). Here we describe a novel pVHL-independent mechanism of HIF regulation and identify nuclear factor (NF)-κB essential modulator (NEMO) as a hitherto unknown oncogeni...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.400
更新日期:2016-06-16 00:00:00
abstract::Accumulating evidences have shown the association between aberrantly expressed microRNAs (miRs) and cancer, where these small regulatory RNAs appear to dictate the cell fate by regulating all the main biological processes. We demonstrated the responsibility of the circuitry connecting the oncomiR-221&222 with the tumo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.357
更新日期:2016-06-09 00:00:00
abstract::Melanoma dedifferentiation, characterized by the loss of MITF and MITF regulated genes and by upregulation of stemness markers as CD271, is implicated in resistance to chemotherapy, target therapy and immunotherapy. The identification of intrinsic mechanisms fostering melanoma dedifferentiation may provide actionable ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.355
更新日期:2016-06-02 00:00:00
abstract::Graft versus host disease (GvHD), which is the primary complication of allogeneic bone marrow transplantation, can alter the intestinal barrier targeted by activated donor T-cells. Chemical inhibition of the stress protein HSP90 was demonstrated in vitro to inhibit T-cell activation and to modulate endoplasmic reticul...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.242
更新日期:2016-06-02 00:00:00
abstract::Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; howev...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2015.318
更新日期:2016-05-12 00:00:00
abstract::In both humans with long-standing ulcerative colitis and mouse models of colitis-associated carcinogenesis (CAC), tumors develop predominantly in the distal part of the large intestine but the biological basis of this intriguing pathology remains unknown. Herein we report intrinsic differences in gene expression betwe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.307
更新日期:2016-05-12 00:00:00
abstract::Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and KRAS, primarily GNAS(R201H) and KRAS(G12D). GNAS encodes the stimulatory G-protein α subunit (Gsα) that medi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.294
更新日期:2016-05-05 00:00:00
abstract::Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27. These pivotal epigenetic marks are altered in many cancers, including melanoma, as a result of EZH2 overexpression. Here, we show that the non-canonical-NF-kB pathway accounts for mo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.331
更新日期:2016-05-01 00:00:00
abstract::Dysregulated microRNA (miRNA) mediate malignant phenotypes, including metabolic reprogramming. By performing an integrative analysis of miRNA and metabolome data for the NCI-60 cell line panel, we identified an miRNA cluster strongly associated with both c-Myc expression and global metabolic variation. Within this clu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.333
更新日期:2016-05-01 00:00:00
abstract::Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence of metastases. We and others demonstrated that nuclear ErbB-2 (NErbB-2) also plays a key role in BC and is a poor prognostic factor in ErbB...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.281
更新日期:2016-04-28 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach. Thus, there is a strong need for novel therapies, targeting more directly the molecular aberrations of...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.270
更新日期:2016-04-21 00:00:00
abstract::Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally expos...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.243
更新日期:2016-04-14 00:00:00
abstract::The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulat...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.261
更新日期:2016-04-14 00:00:00
abstract::The chromatin organizer SATB1 has been implicated in the development and progression of multiple cancers including breast and colorectal cancers. However, the regulation and role of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression of SATB1 is induced upon hyperactivation of Wnt/β-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.232
更新日期:2016-03-31 00:00:00
abstract::Sex-determining region Y box 6 (SOX6) has been described as a tumor-suppressor gene in several cancers. Our previous work has suggested that SOX6 upregulated p21(Waf1/Cip1)(p21) expression in a p53-dependent manner; however, the underlying mechanism has remained elusive. In this study, we confirmed that SOX6 can suppr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.234
更新日期:2016-03-31 00:00:00
abstract::Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.220
更新日期:2016-03-24 00:00:00
abstract::Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired drug resistance are unknown. We show for the first time that, to induce apoptosi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.213
更新日期:2016-03-24 00:00:00